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Which best defines the Columbian Exchange? A. The transfer of people, diseases, plants, and animals between the Old and New Worlds. B. Columbus's establishment of new trade routes between the Old and New Worlds. C. Columbus's transfer of gifts of gold and jewels from Native American leaders to Ferdinand and Isabella of Spain. D. The mass migration of Native Americans to Europe and Africa.
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: Understand the Columbian Exchange

The Columbian Exchange refers to the widespread transfer of plants, animals, culture, human populations, technology, and diseases between the Old World (Afro-Eurasia) and the New World (the Americas) following Christopher Columbus's voyages in 1492.

Final Answer

The transfer of people, diseases, plants, and animals between the Old and New Worlds.