Psychotherapy: 123b - Substance Use Disorders
This flashcard set explores the motivational model of alcohol use, identifying four types—social, conformity, enhancement, and coping—with coping (drinking to reduce negative emotions) carrying the highest risk of dependence. It also compares how different cannabinoids affect the CB1 receptor: THC is a partial agonist (psychoactive), CBD is an antagonist (calming), and synthetic cannabinoids are full agonists, often leading to stronger and more dangerous effects.
According to the motivational model of use, what are the 4 types of motivations for alcohol use?
Which carry the highest risk of alcohol dependence?
External source
Social
Positive valence: drinking is social and fun
Conformity
Negative valence: if I don’t drink, I won’t fit in
Internal source - increased risk of alcohol use disorder
Enhancement
Positve valence: drinking is exciting (even if alone)
Coping - highest risk of alcohol use disorder
Negative valence: drink to not feel sad
Key Terms
According to the motivational model of use, what are the 4 types of motivations for alcohol use?
Which carry the highest risk of alcohol dependence?
External source
Social
How do THC and CBD affect the CB1 receptor?
What about synthetic cannabinoids?
THC = partial agonist -> psychoactive effects
CBD = antagonist -> relaxation
<...List 5 adverse effects of marijuana use that we have “high conficence” in
Cannabis use disorder
Motor vehicle accidents
Which peer group characteristics increase a person’s risk of substance use disorder?
Heavy drinking
Deviant behavior
Which of the 3 FDA approved medications for the treatment of alcohol use disorder has the least evidence for decreasing drinking?
Disulfram
(Naltrexone, acamprosate are the other 2 - good evidence supporting both, nal...
What family factors can increase a person’s risk of substance use disorder?
Parental drinking
Permissiveness
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Term Definition According to the motivational model of use, what are the 4 types of motivations for alcohol use?
Which carry the highest risk of alcohol dependence?
External source
Social
Positive valence: drinking is social and fun
Conformity
Negative valence: if I don’t drink, I won’t fit in
Internal source - increased risk of alcohol use disorder
Enhancement
Positve valence: drinking is exciting (even if alone)
Coping - highest risk of alcohol use disorder
Negative valence: drink to not feel sad
How do THC and CBD affect the CB1 receptor?
What about synthetic cannabinoids?
THC = partial agonist -> psychoactive effects
CBD = antagonist -> relaxation
Synthetic = full agonist at CB1
List 5 adverse effects of marijuana use that we have “high conficence” in
Cannabis use disorder
Motor vehicle accidents
Chronic bronchitis
Diminished lifetime achievement
Development of schizophrenia
Which peer group characteristics increase a person’s risk of substance use disorder?
Heavy drinking
Deviant behavior
Decreased academic competence
Which of the 3 FDA approved medications for the treatment of alcohol use disorder has the least evidence for decreasing drinking?
Disulfram
(Naltrexone, acamprosate are the other 2 - good evidence supporting both, naltrexone is better toldrated but not good for anyone with liver failure or on opioids)
What family factors can increase a person’s risk of substance use disorder?
Parental drinking
Permissiveness
Lower levels of bonding and support
What adverse events migth increase a person’s risk of substance use disorder?
Emotional neglect
Emotional abuse
Sexual abuse
What might make the use of synthetic cannabinoids more dangerous than marijuana?
Synthetic cannabinoids are full agonists at the CB1 receptor
Risks
Extreme anxiety
Confusion
Psychosis
A patient explains that they drink to relax, expecially when they are bored or frustrated with work or their relationship
What is their motivation for drinking? (of the 4 motives)
Coping
This motivation carries the highest risk of alcohol use disorder
What is the genetic contribution to substance use disorder?
Genetics contribute 50% of the risk for alcohol use disorder
Low sensitivity to alcohol = higher risk of substance use disorder
Which hormone is affected by most drugs of abuse?
Dopamine
Increase dopamine release when using
But downregulate dopamine D2 receptor long term
Reverses if person stops using the drug, but the pathway is “already built”; relapse is easier than starting initially
What social/cultural factors can increase a person’s risk of a substance use disorder?
Norms/expectations of substance use
Role model use
How likely are symptoms of depression to resolve with abstinence alone in a patient with alcohol use disorder, who is actively engaging in heavy episodic drinking?
50%
What medications can be used to treat alcohol dependence?
Naltrexone
Mu opioid receptors antagonist
Well tolerated
Do not use in people with liver disease
Acamprosate
Inhibits NMDA receptors -> decreased alcohol craving
Need to dose 3x daily, harder to adhere to
GI upset is a side effect
Disulfram
Irreversivly inhibits acetaldehyde dehydrogenase
Least evidence to support use in treating alcohol dependence
Which psychosocial treatments are most effective for substance use disorders?
Motivational interviewing
12 step lans
CBT
Contingency management
Lose license if you fail a urine tox
Keep job if you complete the 12 step program
Couples and family therapy
In a person with alchohol use disorder and depression, how will abstinence from alcohol affect depression?
Abstinence from alcohol is likely to improve depression
50% of depression resovles in 1 month with abstinence alone