QQuestionAnatomy and Physiology
QuestionAnatomy and Physiology
"Which of the following statements are true about DNA polymerase? Select all that apply.
A. On the leading strand, it works toward the replication fork.
B. It starts replication at one end and then switches sides and continues on to the other strand.
C. On the lagging strand, it works away from the replication fork.
D. It adds nucleotides from the 5' end of the DNA toward the 3' end."
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Answer
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Step 1:Let's solve this step by step:
Step 2:: Understanding DNA Polymerase Directionality
DNA polymerase has specific directional characteristics during DNA replication: - DNA polymerase can only add nucleotides in the 5' to 3' direction - This means it always synthesizes new DNA strands from the 5' end toward the 3' end
Step 3:: Analyzing the Leading Strand
- On the leading strand, DNA polymerase moves continuously in the same direction as the replication fork - This means it works TOWARD the replication fork - Statement A is TRUE
Step 4:: Analyzing the Lagging Strand
- On the lagging strand, DNA polymerase works in short segments called Okazaki fragments - These fragments are synthesized AWAY from the replication fork - Statement C is TRUE
Step 5:: Examining Replication Mechanism
- DNA polymerase does not start at one end and switch sides - It works continuously on the leading strand - On the lagging strand, it creates multiple Okazaki fragments - Statement B is FALSE
Step 6:: Directional Confirmation
- DNA polymerase always adds nucleotides from the 5' end toward the 3' end - Statement D is TRUE
Final Answer
The true statements are A, C, and D.
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