QQuestionBiochemistry
QuestionBiochemistry
"Select all of the following that apply to missense mutations.
They are often harmful or even fatal.
They are a type of point mutation.
They potentially, but rarely, result in a better protein.
The sickle cell mutation in hemoglobin is an example.
They involve the replacement of one DNA nucleotide with another."
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Answer
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Step 1:Let's solve this problem step by step:
Step 2:: Understand Missense Mutations
A missense mutation is a type of point mutation where a single nucleotide change results in a different amino acid being incorporated into the protein during translation.
Step 3:: Evaluate Each Statement
Step 4:"They are often harmful or even fatal"
- $$\checkmark$$ Correct.
Most missense mutations alter the protein's structure or function, which can be detrimental to the organism.
Step 5:"They are a type of point mutation"
- $$\checkmark$$ Correct.
Missense mutations are specifically defined as point mutations where one nucleotide is replaced by another.
Step 6:"They potentially, but rarely, result in a better protein"
- $$\checkmark$$ Correct.
While rare, some missense mutations can occasionally improve protein function through evolutionary processes.
Step 7:"The sickle cell mutation in hemoglobin is an example"
- $$\checkmark$$ Correct.
The sickle cell mutation is a classic example of a missense mutation where a single nucleotide change alters hemoglobin's structure.
Step 8:"They involve the replacement of one DNA nucleotide with another"
- $$\checkmark$$ Correct.
This is the fundamental definition of a missense mutation.
Final Answer
All five statements are correct and apply to missense mutations.
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