QQuestionBiology
QuestionBiology
Arrange the following events of coagulation in the correct order:
Damaged tissue or blood vessels release coagulation factors.
Factor X is activated.
Prothrombinase combines with factor X.
Prothrombin is converted to thrombin.
Fibrinogen is converted to fibrin.
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Answer
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Step 1:
Damaged tissue or blood vessels release coagulation factors: When tissue is damaged or blood vessels are injured, coagulation factors stored in the damaged cells are released. These factors initiate the coagulation cascade.
Step 2:
Factor X is activated: The extrinsic and intrinsic pathways of the coagulation cascade lead to the activation of factor X. In the extrinsic pathway, tissue factor (TF) released from damaged tissue binds to factor VIIa, activating factor X (Xa). In the intrinsic pathway, factor IXa, activated by factor VIIIa, forms the tenase complex that also activates factor X.
Step 3:
Prothrombinase combines with factor X: Factor Xa binds to factor Va on the surface of activated platelets, forming the prothrombinase complex. This complex converts prothrombin (factor II) into thrombin (factor IIa).
Step 4:
Prothrombin is converted to thrombin: The prothrombinase complex (factor Xa-Va) catalyzes the conversion of prothrombin (factor II) to thrombin (factor IIa) on the surface of activated platelets. Thrombin plays a crucial role in the coagulation cascade, activating factors V, VIII, and XI, and converting fibrinogen to fibrin.
Step 5:
Fibrinogen is converted to fibrin: Thrombin cleaves fibrinogen (factor I) into fibrin monomers, which then polymerize to form a stable fibrin clot. This clot provides a framework for the recruitment of platelets and the deposition of additional fibrin, ultimately leading to the formation of a hemostatic plug.
Final Answer
The correct order of events in the coagulation cascade is: 1. Damaged tissue or blood vessels release coagulation factors. 2. Factor X is activated. 3. Prothrombinase combines with factor X. 4. Prothrombin is converted to thrombin. 5. Fibrinogen is converted to fibrin.
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