Biology - Meiosis and Gamete Formation

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Study GuideBiologyMeiosis and Gamete Formation1. MeiosisMost plant and animal cells arediploid.The worddiploidcomes from the Greek worddiplos, meaning “double.” This means diploid cells havepairs of chromosomes.For example, human body cells contain46 chromosomes, arranged into23 pairs. Because thereare two copies of each chromosome, human body cells are diploid.1.1 Diploid vs. Haploid CellsSexual reproduction involves special cells calledgametes(sex cells).In humans, gametes aresperm cellsandegg cellsGametes arehaploid, meaning they containonly one set of chromosomesThe wordhaploidcomes from the Greek wordhaplos, meaning “single.”Human gametes contain23 chromosomes, which is half of the usual 46.When a sperm and an egg join during fertilization, they form azygote.This restores thediploid number (46 chromosomes). After that,mitosisallows the zygote to growinto a multicellular organism.1.2 What Is Meiosis?Meiosisis the type of cell division that produces gametes.Its main purpose is to:Cut the chromosome number in halfProducefour haploid cellsfromone diploid cellIn humans, this means:

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Study GuideOne cell with46 chromosomesDivides to formfour cells, each with23 chromosomes1.3 The Two Stages of MeiosisMeiosis happens intwo major divisions:1.Meiosis I2.Meiosis IIEach division includes the same basicphases seen in mitosis:ProphaseMetaphaseAnaphaseTelophaseHowever, meiosis has important differences that make it unique.1.4 Homologous ChromosomesChromosomes exist inpairscalledhomologous chromosomes.One chromosome comes from eachparentThey are similar butnot identicalThey may carry different versions of the same geneFor example, one chromosome may code for blond hair, while its partner codes for black hair.1.5 Preparing for MeiosisBefore meiosis begins, the cell goes through theS phaseof the cell cycle.Each chromosome is copiedEvery chromosome now consists oftwo sister chromatidsThese chromatids are joined at a structure called thecentromere

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Study Guide1.6 Meiosis I: The Reduction DivisionAt the start of meiosis I, a human cell has:46 chromosomes92 chromatids1.6.1 Prophase IThis stage is very important.Chromosomes condense and become visibleSynapsisoccurs: homologous chromosomes pair upEach paired group forms atetrad(four chromatids total)Another key event here iscrossing over:DNA segments are exchanged between chromatidsThis createsnew genetic combinationsCrossing over increasesgenetic variationIt plays a major role in evolutionAfter crossing over, homologous chromosomes are genetically different.1.6.2 Metaphase ITetrads line up at theequatorial plate(center of the cell)Spindle fibers attach to the centromeresEach centromere attaches toone spindle fiber1.6.3 Anaphase IHomologous chromosomes separate
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