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EukaryoticCellCycleCancer - Document preview page 1

EukaryoticCellCycleCancer - Page 1

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EukaryoticCellCycleCancer

Explore how the eukaryotic cell cycle drives growth, repair, and development in organisms. Learn the role of growth factors, why cell division matters for adults, and its link to cancer. Great for biology students!

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EukaryoticCellCycleCancer - Page 1 preview imageBifrlrn*ractiv«Click & LearnSiudenT WorksheetTheEukaryotic Coll Cycle and CancerIn DepthTo use this document first read the Instructions andFAQs This document is made available by the Howard HughesMedical Institute. Using this document you agree touse fh*5 document >vraccordance wrfh the Terms ofUse.INTRODUCTIONThis handout complements the Click St Learn The Eukaryotic CetJCycle and Cancer andis intended as anin-depth examination of the cell cycle and the protein players involved. For a more general overview, please seethe overview version.PROCEDUREFollow the instructions as you proceed through the Click a Learn and answer the questions in the spaces below.Click on the "Background" tab on the right side.1.Compare and contrast the reasons cell division is important for unicellular (single-celled) and multicellularorganisms.Cell division is the only way single-celled organisms can reproduce whereas for multicellular organisms it is theonly way to grow and repair dam aged ceIls.2.Provide an example of why cell division remains important to an adult organism even after it is fullydeveloped.After growth, division remains important innormalcell turnover, such asin skinandgul.where cells arecontinuously renewed Other cells have to divide to heal wounds like skin cuts or broken bones.3.What is the role of growth factors?Growth factors are the ligands reeded to activate a signal transduction pathway to result in cell division as acellular response.4Cells djyide, differentiate, or die. What is differentiation?Differentiation is the process when cells become specialized in structure and function. During differentiationcells develop specific characteristics that allow them to perform a particular role within the body. Someexamples are, cells may differentiate into muscle cells, nerve cells, or skin cells, each with unique structuresand functions.5.What is apoptosis? Explain its purpose.Apoptosis is a natural process by tvhich cells in a living organism intentionally self-destruct. It is a carefullyregulated process that plays an essential role in development and the maintenance of healthy tissues.The purpose of apoptosis is to eliminate unnecessary, damaged, or potentially harmful cells, which couldotherwise interfere with the normal functioning of the organism.CellCydem m . E cTE-scwe.crjUpctated FefiruB2OZCF a r s i of 10
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EukaryoticCellCycleCancer - Page 2 preview imagehhBMnterftttfeaThe Eukaryotic Ceti Cycle and Cancer - In DepthClick & LearnStudent WtKfcsbwt6Organisms maintain the right number of cells by regulating the cell cycle. What are "cel[cycle regulators?"Cell cycle regulators are molecular signals that may stimulate or halt cell division, instruct cells to differentiate,or initiate cell death.7.Watchthe video clip of cells in the small intestine.Name the general location along the villus where thefollowing processes occur:Cell Division:cryptCell Differentiation:Lining of the villus nearthe cryptApoptosis:villus8.Name one harmless result of too little cell division.Hair LossName one harmless result of too much cell division.WartsClick on the section of the circle labeledCell Cycle Phases" in the center purple circle on the right and usethe "Overviewinformation in the window on the left to answer the questions belov/.10. List, in order, the four events we collectively call the ' cell cycle." Next to each event, write the correlatingcell cycle phase name.a.growth-G1 Phaseb.DNA replicationphasec.preparation to divide-G2 Phaseddivision -Mitotic phase11. Ir general, what is the purpose of a checkpoint in the cell cycle?(checkpoint proteins" regulate the progression from one phase of the cell cycle to the next.The progression through these checkpoints is a strictly regulated process that usually workswithout errors.12. What is one potential outcome when errors occur in this highly regulated cell cycle process?C e l l C y d eiw.w.E.c T E i c r . ' t . c r jJexisted FeotB-f 2CQCP B g e Z c j f i D
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EukaryoticCellCycleCancer - Page 3 preview imageMtanBkolnlBractivoClick & LearnThe Eukaryotic Cell Cycle and Cancer - In DepthStudent WorksheetWhen errors do occur, they can have catastrophic consequences, including the developmentof cancer.Click on"Cell Cycle Regulators and Cancer' in the center purple circleonthe right. Use theinformation under'Regulators Overview"in thewindow on the left to answer the questions below.13. What type of protein that regulates the cell cycle is encoded by proto-oncogenes?Stimulating proteins (encoded by proto-oncogenes)14. What type of protein that regulates the cell cycle is encoded by tumor suppressor genes?Inhibitory proteins (encoded by tumor suppressor genes)15. The most Important cell cycle regulators are theCDKs.16. What is = kinase, and what does it do?Kinases are enzymes that add a phosphate to other proteins to activate or inhibit theirfunction—a process known as phosphorylation.17. When are CDKs present inside the cell during the cell cycle?CDKs are always present in the cell but become active only when they are bound to otherproteins called cyclins,IS. When are cyclins present inside the cell during the cell cycle?cyclin concentration inside the cell cycles varies up and down, depending on the phase ofthe cycle19. CDKs form molecular complexes with cyclins. What do activated CDK-cyclin complexes do?Some proteins activate CDK-cyclin complexes, stimulating the cell cycle. Others inactivateCDK-cyclins or prevent their activation, which inhibits cell cycle progression.Using the cell cycle diagram on the right and both links in the center purple circle, complete the table belowfor each phase. Use bullet points and focus on major events that occur during each phase, checkpoint, andregulatory process. Complete the entire row before moving on to the next phase.PHASEPHASE EVENTSCHECKPOINT EVENTSREGULATORY PROCESSESCeilCydewww.BjrtTteractjre.0r5Jocsted FeCruary 2CCCFare 3of10
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