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Kami Export - Sandra Nichols - Bio-Worksheet-Mutat

This worksheet explains DNA mutations: deletions and insertions cause frameshifts; substitutions can be silent, missense, or nonsense. It shows how mutations change amino acids and includes sickle cell anemia as an example of a missense mutation.

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    NAME * " F ' ' Mutations Worksheet Deletion. Insertion & Substitution * in There are several types of mutation y .. 1 - — ■ DELt 1LON (a base is lost/ deleted) INSERTION (an extra base is added/irserted) — Deletion A insertion may cause what s called a FRAMESHIFT mutation, meaning the reading " f r a m e " charges, thus changing the amino acid sequence from this point forward SUBS 11 1UTION (one base is substituted for another) — I f a substitution changes the amino acid, its called a MISSENSE mutation — I f a substitution does not change the amino acid, its called a 5ILENT mutation — I f a substitution changes the amino acid to a "stop," it's called a NONSENSE mutation \ Complete the boxes below. Classify each as Deletion, Insertion or Substitution A ND os either frameshift, missense, silent or nonsense (Hint; Deletion A Insertion will always be frameshift). 1 Original DNA Sequence: T A C mRNA Sequence: A C C U G G T T G A A C G C G C G C A C G V G C A C T . . U G A Amino Add Sequence: Met Trp Mn M Cjffl Slop Mutated DNA Sequence =1 T A C Whafsthe mRNA sequence? u ft A T C u Q 5 T T G * A C G C G C <5 C A C G U G C AC T ... U ft A (Circle the change) amino add sequence? f.,1ethi Oil i ne-{Stpp) Will chert likely be effects? ■■■ ■ < What type of mutation is this? Subs; till tuition Ncf'is nsf- Mutated DNA Sequence #2 T A C G A C C T TiG G C G A C G A C T ... Whafsthe mRNA sequence? A U G C)UG 3 A A C C G C U G C U G A (Circle the change) amino add sequence? Mel Set C , u Pro Leu Pro Will there likely he effects? Yes What type of mutation 15 tiu 5 ? |T seMiori Frame Shifl---------------------------------- Mutated DNA Sequence #3 T A C A C C T T A G C G A C G1A C T... Whafsthe mRNA sequence? AUG U G G A A ® C G C U G C U G A (Circle the change) amino add sequence? Trp A«n Str Cy« Slap Will there likely be effects? What type of mutation is this? Sctshtutisi- i lent V_tat.oi. __________ Mutated DNA Sequence £4 T A C A C C T T H T G C G A C T A C T... Whafs the mRNA sequence? A U G U G G A A C C G C U G U G A (Circle the change) amino add sequence? Mel Trp Ash Arg Stop Stop Will there likely be effects? yes — hat type of mutation is this? s;.a-<,nuiinii h ________________

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