Genetics: A Conceptual Approach, 6th Edition Solution Manual

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Answers to Chapter Opening and End-of-Chapter Think-Pair-Share Questions: Pierce Genetics 6eChapter 1Think-Pair-Share questions for the chapter opening story:Albinism occupied a special place in the Hopi culture; individuals who possessed thistrait were valued by members of the tribe. What are some examples of genetic traits that,in contrast, sometimes result in discrimination and prejudice?Possible Answers: People with many genetic traits are exposed to discrimination andprejudice. Indeed, people with albinism in cultures other than the Hopis are subjected todiscrimination for the way they look. In the past, African Americans who wereheterozygous carriers of the mutation for sickle-cell anemia were subject todiscrimination in employment and insurance, even though they were perfectly healthy.Skin color is a genetically determined characteristic and there is discrimination againstpeople with certain skin colors in some societies. Students may have witnesseddiscrimination against people with a variety of genetically determined characteristics.Albinism in humans can be caused by mutations in any one of several different genes.This situation, in which the same phenotype may result from variation in several differentgenes, is referred to as genetic heterogeneity. Is genetic heterogeneity common? Are mostgenetic traits in humans the result of variation in a single gene, or are there many genetictraits that result from variation in several genes, as albinism does?Possible Answers: Beginning genetics students often have the misconception that mosttraits are caused by a single variation at a single gene, much like the traits Mendel studiedin his pea plants. This question provides an opportunity at the beginning of the course todiscuss this misconception and the fact that the genetic basis of most traits is morecomplex.Many genetic traits and diseases exhibit genetic heterogeneity, where DNA sequences atany one of several different genes can result in the same phenotype. For example,albinism in the Hopis is caused by mutations in theOCA2gene, but mutations at severalother genes may produce albinism in other populations. Genetic heterogeneity can alsoresult from different mutations at the same gene. Both types of heterogeneity are seen in

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