1.9 Enzyme Inhibition

Biochemistry4 CardsCreated 3 months ago

Competitive inhibitors resemble the substrate and temporarily bind to the active site, reducing enzyme activity—but their effect can be reduced by increasing substrate concentration. Non-competitive inhibitors bind elsewhere on the enzyme, altering the active site’s shape, and their effect remains unchanged regardless of substrate concentration.

Describe how competitive inhibitors work

  • similar molecular shape to the substrate
    -bind to the active site to prevent the substrate from binding

  • not permanent

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Key Terms

Term
Definition

Describe how competitive inhibitors work

  • similar molecular shape to the substrate
    -bind to the active site to prevent the substrate from binding

  • not permanent

    ...

What is the effect of increasing substrate concentration on competitive inhibitors?

  • the effect on the inhibitor is reduced

Describe how non competitive inhibitors work

  • Attach to a binding site which is not the active site
    -Breaks bonds within the protein which alters the shape of the active site
    -Sub...

what is the effect of increasing substrate concentration on non-competitive inhibitors

no effect as inhibitor and substrate are not competing for the same active site

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TermDefinition

Describe how competitive inhibitors work

  • similar molecular shape to the substrate
    -bind to the active site to prevent the substrate from binding

  • not permanent

What is the effect of increasing substrate concentration on competitive inhibitors?

  • the effect on the inhibitor is reduced

Describe how non competitive inhibitors work

  • Attach to a binding site which is not the active site
    -Breaks bonds within the protein which alters the shape of the active site
    -Substrate is no longer complementary to the enzyme so cannot bind

what is the effect of increasing substrate concentration on non-competitive inhibitors

no effect as inhibitor and substrate are not competing for the same active site