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2024-2025 Autoimmune hematologic Disorders (PEARLS) (Smarty PANCE) with Answers (45 Solved Questions)

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    Autoimmune hematologic disorders (PEARLS) (Smarty PANCE) 100% VERIFIED ANSWERS 2024/2025 CORRECT Anemias can be broadly grouped into 3 categories based on what ? Anemias can be broadly grouped into 3 categories based on mean corpuscular volume , or MCV, which reflects the volume of a red blood cell. What are the 3 broadly grouped categories of anemia based on MCV? 1. Microcytic: MCV is lower than 80 fL, 2. Normocytic: MCV between 80 and 100 fL 3. Macrocytic: MCV larger than 100 fL. Normocytic anemias can be further classified as what? Normocytic anemias can be further classified as 1. Hemolytic when there's increased destruction of RBCs 2. Non - hemolytic when there's decreased production of RBCs from the bone marrow Hemolytic anemia i s a ___________? Normocytic anemia

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    How do you distinguish between hemolytic and non - hemolytic normocytic anemias? When there's hemolysis, the bone marrow revs up and starts pumping out immature RBCs called reticulocytes , but when there's a bone marrow prob lem reticulocyte count is low. So for your exams, it's important to know that in hemolytic anemias there's an increased reticulocyte production index of over 2%, while in non - hemolytic anemias it's lower than 2%. In hemolytic anemia the reticulocyte count will be _______? High > 2% How are hemolytic anemias classified? Hemolytic anemias can be classified as intrinsic and extrinsic hemolytic anemias Intrinsic hemolytic anemias? In intrinsic hemolytic anemias , the RBCs are destroyed due to RBC membrane defect s , like in hereditary spherocytosis and paroxysmal nocturnal hemoglobinuria , or PNH ; enzyme deficiencies, like in G6PD deficiency and pyruvate kinase deficiency ; and hemoglobin abnormalities, like in sickle cell anemia . Extrinsic hemolytic anemias? In extr insic hemolytic anemias, the RBCs are normal but are later destroyed via extrinsic mechanisms such as autoantibodies directed against RBCs. Extrinsic hemolytic anemias that include autoimmune hemolytic anemia , microangiopathic hemolytic anemia , macr oangiop athic hemolytic anemia and infections . How is intrinsic hemolysis divided?

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