2017 PHARM-615 Pharmacology Practice Exam With Answers (88 Solved Questions)

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615-PHARM EXAM 2 SUPER-DUPER Q&A 20171.Henry has recently started on carbamazepine to treat seizures. He comes to see you andyou note that while his carbamazepine levels had been in the therapeutic range, theyare now low. The possible cause for the low carbamazepine levels include:Carbamazepine auto-induces metabolism, leading to lower levels despite goodcompliance.2.Carbamazepine has a Black Box Warning due to life-threatening:Dermatologic reaction, including Steven’s Johnson and toxic epidermal necrolysis3.Long-term monitoring of patients who are taking carbamazepine includes:Complete blood count every 3 to 4 months (can be a decrease in WBC & platelets)4.Six-year-old Felisha has recently been started on ethosuximide (Zarontin) for seizures.She should be monitored for:Blood dyscrasias, which are uncommon but possible5.What should families be taught regarding seizure activity monitoring?Prevention of seizures, patient safety, quality of life issues, reach acceptable goals fortreatment, & do not abruptly stop taking seizure meds6.What electrolyte imbalance is associated with topiramate?Decreased sodium bicarb leading to hyperchloremic metabolic acidosis7.Lisa, who is overweight, recently started taking topiramate for seizures and at her follow-up visit you note she has lost 4 kg. The appropriate action would be:Reassure her that this is a normal side effect of topiramate and continue to monitor herweight.8.Travis’s seizures are well controlled on topiramate and he wants to start playing baseball.Education for Travis regarding his topiramate includes:He should monitor his temperature and ability to sweat in the heat while playing9.Brandy is taking valproate (Depakote) for seizures and would like to get pregnant. Whatadvice would you give her?

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Valproate is a known teratogen, but may be taken after the first trimester if necessary.Keppra is a better drug to be on until the second trimester, then she can go back tovalproate.10. What category is valproate?Category X11. The tricyclic antidepressants should be prescribed cautiously in patients with:Heart disease12. A 64-year-old male was prescribed phenelzine (Nardil) while in an acute psychiatric unitfor recalcitrant depression. The NP managing his primary health care needs tounderstand the following regarding phenelzine and other monoamine oxidase inhibitors(MAOIs):He should not be prescribed any serotonergic drug such as sumatriptan (Imitrex), MAOIsinteract with many common foods, including yogurt, sour cream, and soy sauce, andsymptoms of hypertensive crisis (headache, tachycardia, sweating) require immediatetreatment13. What are the precautions and contraindications for tricyclic antidepressants?Side effects are similar to anticholinergic activity such as dry mouth, sedation,constipation, increased appetite, blurred vision, tinnitus, euphoria, and mania. Cautionin patients with cardiac disease (terminate ventricular fibrillation, decrease cardiaccontractility, increase collateral blood circulation to ischemic heart muscles).14. Marla is started on paroxetine (Paxil), a selective serotonin reuptake inhibitor (SSRI), fordepression. Education regarding her antidepressant includes:SSRIs may take 2 to 6 weeks before she will have maximum drug effects.15. What “onset of action” symptoms should be reviewed with patients who have beennewly prescribed a selective serotonin reuptake inhibitor?They can feel a bit of nausea, but this resolves in a week.16. Which of the following should not be taken with a selective serotonin reuptakeinhibitor?Alcohol

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17. Why is the consistency of taking paroxetine (Paxil) and never running out of medicationmore important than with most other selective serotonin reuptake inhibitors (SSRIs)?It has a shorter half-life and withdrawal syndrome has a faster onset without taper18. Janet presents with depression associated with complaints of fatigue, sleeping all thetime, and lack of motivation. An appropriate initial antidepressant for her would be:Duloxetine (Cymbalta)19. A patient with anxiety and depression may respond to:Buspirone (Buspar) and an SSRI combined20. When is buspirone (Buspar) and an SSRI combined?Buspar is helpful in augmenting the SSRI and in treating patients with agitated oranxious depression21. An appropriate first-line drug to try for mild to moderate generalized anxiety disorderwould be:Buspirone (Buspar)22. Larry has been prescribed citalopram (Celexa) to treat his depression. Educationregarding how quickly selective serotonin reuptake inhibitor (SSRI) antidepressants workwould be:Appetite and concentration improve in the first 1 to 2 weeks23. An appropriate drug for the treatment of depression with anxiety would be:Escitalopram (Lexapro)24. One major drug used to treat bipolar disease is lithium. Because lithium has anarrow therapeutic range, it is important to recognize symptoms of toxicity, such as:Drowsiness and nausea25. Simon is taking lithium for bipolar disorder. He should be taught to:Eat a diet with consistent levels of salt (sodium)26. What are the side effects of tricyclic antidepressants?Dry mouth, constipation, urinary hesitancy or retention, blurred vision, sedation,orthostatic hypotension, weight gain, N/V, gynecomastia, and changes in libido.

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