Addiction Medications TableWeek BCH O WBl. M NH M V n t M T V“HIS ASSIGNMENT SHOULD BE SUBMITTED TO THE WEEK 5 MEDICATION TABLE DROPBOX BY SUNDAY AT 11 59 P.M. MT.Drug NameIndicationNeurotransmitterfs)AffectedTarget SymptomsHalf-life (Tl'2),Metabolism (CYP 450enzyme)Notable Side Effects(link to NT or affectedbrain circuit)Initial DosingConsiderationsSpecific lifespanconsiderations(age, pregnancy,breastfeeding)Buprenorphine(Subutex)Indication:Maintenancetreatment of opioiddependenceMaintenancetreatment of opioiddependence inpatients who haveachieved andsustained prolongedclinical stability onlow-to moderatedoses of a transmucosalbuprenorphinecontaining productModerate to severeopioid use disorder inpatients who haveinitiated treatmentwith a transmucosal24-42hoursCYP450:CYP3A424-42hoursCYP450:CYP3A4Half-life: 24-42 hoursCYP450: CYP3A4Headache,constipation, nauseaOral hypoesthesia,glosscdyniaOrthostatichypotensionRespiratory distressHepatotoxicityBinds to mu opioidreceptorsInitial dosing:Sublingual 8-32mg dayControlled studieshave not beenconducted inpregnant women.Buprenorphinemay be preferableto methadone inpregnant women.Neonatal opioidwithdrawalsyndrome has beenreported followinguse ofBuprenorphineduring pregnancySome drag isbuprenorphinecontaining product,followed by doseadjustment for aminimum of 7 daysNeurotransmitteraffected: Mu opioidreceptor partialagonist Antagonist atthe kappa opioidreceptorTarget symptoms:Opioid dependencefound in mother'sbreast milk.Recommendedeither todiscontinued drugor formula feed.Use with cautionin elderly. Somepatients maytolerate lowerdoses better.Buprenorphine Naloxone(Suboxone, Zubsolv,Bunavail)Indication:Treatment, andmaintenance ofopioid dependence.Induction oftreatment for opioiddependenceMaintenancetreatment of opioiddependence inpatients who haveachieved andsustained prolongedclinical stability onlow-to moderateSuboxone: 24-42 hoursNaloxone: 2-12 hoursCYP450: CYP3A4Headache,constipation, nausea,oral hypcesthesia,glosscdynia,orthostatichypotension, sedationBinding at mu opioidreceptorsInitial dosing:Bunavail: Day 1:induction dose:Initial: Buccal:Buprenorphine 2.1mg naloxone 0.3mg; may repeatdose after 2 hours,based on control ofacute withdrawalsymptoms;maximum totaldose:buprenorphine 4.2mg naloxone 0.7mg. Day 2:Preview Mode
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